Research Projects

Brockhoff’s reasearch is currently funded by:

• Deutsche Forschungsgemeinschaft
• Deutsche Krebshilfe
• Roche Diagnostics GmbH

Research Projects

• Analysis of ErbB receptor function(s) and the cellular response to antibody therapy / treatment
• Multichromatic ErbB receptor detection - quantitative molecule detection via flow cytometry in tumor diagnosis
• Analysis of molecular mechanisms triggered by therapeutic anti-Her2/neu antibodies Trastuzumab and Pertuzumab in breast cancer cell lines
• Identification of molecular signatures with impact on the cellular response to Herceptin (Trastuzumab) via „cytogenetic immunophenotyping“
• Modulation of ErbB receptor signaling in „anti-ErbB” and endocrine cell treatment
• Impact of Her4 RTK co-expression on anti-Her2 and endocrine breast cancer cell treatment
• Preclinical analysis of combined tumor therapy: anti-ErbB-Receptor targeting und radio therapy
• Fully automated Fluorescence-in-situ-Hybridization (M-FISH) for multiplexed tissue diagnosis
• Immunmodulation of antibody-dependent cellular cytotoxicity (ADCC) in humanized tumor mice to enhance therapy efficiency

You can find an overview about research projects of Prof. Dr. Brockhoff from 2003 – 2006 at the 10th Research report of the University of Regensburg.

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