Wissenschaftliche Aufsätze 2012 Ettl T, Baader K, Stiegler C, Müller M, Agaimy A, Zenk J, Kühnel T, Gosau M, Zeitler K, Schwarz S, Brockhoff G: Loss of PTEN function is associated with EGFR and HER2 signalling in high-grade salivary gland cancer. Br J Cancer. 2012 Jan 12. doi: 10.1038/bjc.2011.605. [Epub ahead of print] 2011 Viale-Bouroncle S, Felthaus O, Schmalz G, Brockhoff G, Reichert T, Morsczeck C: The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells. Stem Cells Dev. 2011 Nov 22. [Epub ahead of print]
Ettl T, Stiegler C, Zeitler K, Zenk J, Hartmann A, Reichert TE, Kühnel T, Brockhoff G, Schwarz S: EGFR, HER2, Survivin and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis and therapy. Hum Pathol. 2011 Dec 9. [Epub ahead of print] Lehner B, Sandner B, Lehner C, Marschallinger J, Lehner C, Furtner T, Couillard-Despres S, Rivera, F, Brockhoff G, Bauer HC, Weidner N, Aigner L: The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival. Cell Tissue Res. 2011 Sep;345(3):313-282011 Aug 12. Diermeier-Daucher D, Breindl S, Wege AK, Buchholz S, Ortmann O, Brockhoff G: Modular anti-EGFR and Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB-receptor specific growth factors. Cytometry A. 2011 Jul 22. doi: 10.1002/cyto.a.21107. [Epub ahead of print] Viale-Bouroncle S, Brockhoff G, Völlner F, Möhle C, Küpper K, Reichert TE, Schmalz G, Morsczeck C: Soft matrix osteogenic differentiation of human dental follicle cells. Biochem Biophys Res Co. 2011 Jul 8;410(3):587-92 Wege AK, Ernst W, Vollmann-Zwerenz A, Männel DN, Ortmann O, Kroemer A, Brockhoff G: Humanized tumor mice - a new model to study and manipulate the immunological response in advanced cancer. Int J Cancer. 2011 May 4. doi: 10.1002/ijc.26159. [Epub ahead of print] Plander M, Seegers S, Orsó E, Schmitz G, Hofstädter F, Ugocsai P, Brockhoff G: Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma. Ann Hematol. 2011 Apr 5. [Epub ahead of print] Brockhoff G, Bock M, Gantner S, Hafner C: No evidence for ErbB4-gene amplification in malignant melanoma. Acta Derm Venereol 2011 Jun;91(4):488-90. Schwarz S, Stiegler C, Müller M, Ettl T, Brockhoff G, Zenk J, Agaimy A: Salivary Gland Mucoepidermoid Carcinoma is a Clinically, Morphologically and Genetically Heterogeneous Entity. A Clinicopathologic Study of 40 Cases with Emphasis on Grading, Histological Variants and Presence of the t(11;19) Translocation. Histopathology. 2011 Mar;58(4):557-70. Felthaus O, Ettl T, Gosau M, Driemel O, Brockhoff G, Reck A, Zeitler K, Hautmann M, Reichert TE, Schmalz G, Morsczeck C: Cancer stem cell-like cells from a single cell of oral squamous carcinoma cell lines. Biochem Biophys Res Commun. 2011 Apr 1;407(1):28-33. Epub 2011 Feb 20
2010
Berezowska S, Diermeier-Daucher S, Brockhoff G, Busch R, Duyster J, Grosu AL, Schlegel J: Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells. Int J Mol Med. 2010 Nov;26(5):713-2 Brunner K, Fischer CA, Driemel O, Hartmann A, Brockhoff G, Schwarz S. EGFR (HER) family protein expression and cytogenetics in 219 squamous cell carcinomas of the upper respiratory tract: ERBB2 overexpression independent prediction of poor prognosis. Anal Quant Cytol Histol. 2010 Apr;32(2):78-89. Rasper M, Brockhoff G, Piontek G, Teufel J, Ringel F, Zimmer C, Schäfer A, Schlegel J: Aldehyde Dehydrogenase 1 Positive Glioblastoma Cells Show Brain Tumor Stem Cell Capacity. Neuro Oncol. 2010 Oct;12(10):1024-33. Wohlschlaeger J, Levkau B, Brockhoff G, Schmitz KJ, von Winterfeld M, Takeda A, Takeda N, Stypmann J, Vahlhaus C, Schmid C, Pomjanski N, Böcking A, Baba HA: Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart. Circulation. 2010 Mar 2;121(8):989-96. Vollmann-Zwerenz A, Diermeier-Daucher S, Wege AK, Sassen A, Schmidt-Brücken E, Hofstaedter F, Ortmann O, Nauwelaers F, Brockhoff G: Multichromatic phenotyping of ErbB receptor coexpression in breast tumor tissue samples using flow cytometry – Possibilities and limitations. Cytometry A. 2010 Feb 11;77A(4):387-398. Pohl F, Grosse J, Grimm D, Brockhoff G, Schmidt-Bruecken E, Westphal K, Moosbauer J, Koelbl O, Infanger M, Eilles C, Schoenberger J. Changes of apoptosis, p53 and bcl-2 by irradiation in poorly differentiated thyroid carcinoma cell lines – a prognostic marker for prospect of therapeutic success? Thyroid. 2010 Feb;20(2):159-66 2009 Wagner K, Couillard-Despres S, Lehner B, Brockhoff G, Rivera FJ, Blume A, Neumann I, Aigner L. Prolactin induces MAPK signaling in neural progenitors without alleviating glucocorticoid-induced inhibition of in vitro neurogenesis. Cell Physiol Biochem. 2009;24(5-6):397-406. Buchholz S, Seitz S, Schally AV, Engel JB, Rick FG, Szalontay L, Hohla F, Krishan A, Papadia A, Gaiser T, Brockhoff G, Ortmann O, Diedrich K, Köster F. Triple-negative breast cancers express receptors for luteinizing hormone-releasing hormone (LHRH) and respond to LHRH antagonist Cetrorelix with growth inhibition. Int J Oncol. 2009 Oct;35(4):789-96. Plander M, Seegers S, Ugocsai P, Diermeier-Daucher S, Iványi J, Schmitz G, Hofstädter F, Schwarz S, Orsó E, Knüchel R, Brockhoff G: Different Proliferative and Survival Capacity of CLL-Cells in a Newly Established in vitro Model for Pseudofollicles. Leukemia. Nov;23(11):2118-28, 2009 Sassen A, Diermeier-Daucher D, Sieben M, Ortmann O, Hofstaedter F, Schwarz S, Brockhoff G: Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer. Breast Cancer Res. 2009;11(4):R50. Epub 2009 Jul 22. Diermeier-Daucher S, Clarke ST, Hill D, Vollmann-Zwerenz A, Bradford JA, Brockhoff G: Cell type specific applicability of 5-ethynyl-2’-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry. Cytometry A. 2009 Jun;75(6):535-46. 2008 Sassen A, Rochon J, Wild PJ, Hartmann A, Hofstaedter F, Schwarz S, Brockhoff G:
Cytogenetic analysis of HER1/EGFR, HER2, HER3, and HER4 in 278 breast cancer patients. Breast Cancer Res. 2008 Jan 8;10(1):R2 Diermeier-Daucher S, Hasmann M, Brockhoff G: Flow cytometric FRET analysis of erbB receptor interaction on a cell-by-cell basis. Ann N Y Acad Sci. 2008;1130:280-6. Schwarz S, Bier J, Driemel O, Reichert TE, Hauke S, Hartmann A, Brockhoff G: Losses of FHIT and p16 as shown by fluorescence in situ hybridization (FISH) are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis. Cytometry A. 2008 Apr;73(4):305-11 Schwarz S, Rechenmacher M, Filbeck T, Knuechel R, Hartmann A, Brockhoff G: Value of multicolour Fluorescence-in-situ-hybridization (UroVysionTM) in the differential diagnosis of flat urothelial lesions. J Clin Pathol. 2008 Mar;61(3):272-7 Weiss TS, Lichtenauer M, Kirchner S, Stock P, Aurich H, Christ B, Brockhoff G, Kunz-Schughart LA, Jauch KW, Schlitt HJ, Thasler WE. Hepatic progenitor cells from adult human livers for cell transplantation. Gut. 2008 Aug;57(8):1129-38. Gottfried E, Kunz-Schughart L, Rehli M, Kastenberger M, Brockhoff G, Andreesen R, Kreutz M: Expression of CD68 in non-myeloid cell types. Scand J Immunol. May;67(5):453-63, 2008 2007 Denzinger S, Stoehr R, Schwarz S, Eichenseher N, Brockhoff G, Obermann EC, Knuechel R, Blaszyk H, Hartmann A, Wild PJ.: Low level STK15 amplification in histologically benign urothelium of patients with bladder cancer adversely predicts patient outcome following cystectomy. Int J Oncol. 2007 Oct;31(4):793-802. Brockhoff G, Heckel B, Schmidt-Brücken E, Hofstaedter F, Vollmann A, Diermeier S: Differential impact of Cetuximab, Pertuzumab and Trastuzumab on BT474 and SK-BR-3 breast cancer cell proliferation. Cell Prolif. 2007 Aug;40(4):488-507 Schweikl H, Hartmann A, Hiller KA, Spagnuolo G, Bolay C, Brockhoff G, Schmalz G: Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine. Dent Mater. 2007 Jun;23(6):688-95 2006 Schaefer KL, Brachwitz K, Braun Y, Diallo R, Wai DH, Brockhoff G, Vollmann A, Zahn S, Schneider DT, Kuhnen C, Gabbert HE, Poremba C: Constitutive activation of neuregulin / ERBB3 signaling pathway in clear cell sarcoma of soft tissue. Neoplasia. 2006 Jul;8(7):613-22 Vollmann A, Vornlocher HP, Stempfl T, Brockhoff G, Apfel R, Bogdahn U: Glioma cells escape specific siRNA mediated siliencing of EGFR in vitro. Int J Oncol. Jun;28(6):1531-42, 2006 2005 Lottner C, Schwarz S, Diermeier S, Knuechel R, Hofstaedter F, Brockhoff G: Authors' reply. J Pathol. 2005 May 26 Diermeier S, Horvath G, Knuechel R, Hofstaedter F, Szollosi J, Brockhoff G: EGFR coexpression modulates susceptibility to Herceptin in HER2/neu overexpressing breast cancer cells. Exp Cell Res. 2005 Apr 1;304(2):604-19. Lottner C, Schwarz S, Hartmann A, Diermeier S, Knuechel R, Hofstaedter F, Brockhoff G: Simultaneous detection of HER2/neu gene amplification and protein overexpression in paraffin-embedded breast cancer. J Pathol. 2005 Feb 24 Staiger H, Brockhoff G: The role of PDGF-dependent postconfluent mitoses in differentiating 3T3-L1 preadipocytes. Diabetes und Stoffwechsel 2005 14:181-187 Schweikl H, Altmannsberger I, Hanser N, Hiller KA, Bolay C, Brockhoff G, Spagnuolo G, Galler K, Schmalz G: The effect of Triethylene Glycol Dimethacrylate on the cell cycle of mammalian cells. Biomaterials 2005 Jul;26(19):4111-4118 2004 Schwarz S, Rechenmacher M, Lottner C, Brockhoff G, Hartmann A, Langer S, Knuechel R: FISH analysis in the differential diagnosis of flat urothelial lesions using tissue microarrays. Verh Dtsch Ges Pat. 2004 88:184-193 Diermeier S, Schmidt-Brücken E, Kubbies M, Kunz-Schughart LA, Brockhoff G: Continuous Bromodeoxyuridine (BrdU) exposition differentially affects cell cycle progression of human breast and bladder cancer cell lines. Cell Prolif. 2004 Apr;37(2):195-206. 2003 Kunz-Schughart LA, Weber A, Rehli M, Gottfried E, Brockhoff G, Krause SW, Andreesen R Kreutz M: The ‘classical’ macrophage marker CD68 is strongly expressed in primary human fibroblasts. Verh Dtsch Ges Pat. 2003 87:215-223. Ewing P, Wilke A, Brockhoff G, Andreesen R, Eissner G, Holler E, Gerbitz A: Isolation and transplantation of allogeneic pulmonary endothelium derived from GFP transgenic mice. J Immunol Methods. 2003 283:307-315. Brockhoff G, Plander M, Barlage S, Schwarz S, Rothe G, Knuechel R: Optimization of three and four color multiparameter DNA analysis in lymphoma specimens. Cytometry. 2003 Jul;54A(1):66-74. Silzle T, Kreutz M, Dobler MA, Brockhoff G, Knuechel R, Kunz-Schughart LA. Tumor-associated fibroblasts recruit blood monocytes into tumor tissue. Eur J Immunol. 2003 May;33(5):1311-20. 1994 - 2002 Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry. 2002 Jun 1;48(2):80-6. Becke FM, Hehlgans T, Brockhoff G, Maennel DN. Development of allergic contact dermatitis requires activation of both tumor necrosis factor-receptors. Eur Cytokine Netw. 2001 Mar;12(1):45-50. Brockhoff G, Heiss P, Schlegel J, Hofstaedter F, Knuechel R. Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells. Cytometry. 2001 Aug 1;44(4):338-48. Langstein J, Becke FM, Sollner L, Krause G, Brockhoff G, Kreutz M, Andreesen R, Schwarz H. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem Biophys Res Commun. 2000 Jun 24;273(1):117-22. Brockhoff G, Fleischmann S, Meier A, Wachs FP, Hofstaedter F, Knuechel R. Use of a mechanical dissociation device to improve standardization of flow cytometric cytokeratin DNA measurements of colon carcinomas. Cytometry. 1999 Aug 15;38(4):184-91. Ruschoff J, Wallinger S, Dietmaier W, Bocker T, Brockhoff G, Hofstaedter F, Fishel R. Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11301-6. Brockhoff G, Wieland W, Woelfl G, Hofstaedter F, Knuechel R. Evaluation of flow-cytometric three-parameter analysis for EGFR quantification and DNA assessment in human bladder carcinomas. Virchows Arch. 1998 Jan;432(1):77-84 Brockhoff G, Endl E, Minuth W, Hofstaedter F, Knuechel R. Options of flow cytometric three-colour DNA measurements to quantitate EGFR in subpopulations of human bladder cancer. Anal Cell Pathol. 1996 Jun;11(1):55-70. Brockhoff G, Hofstaedter F, Knuechel R. Flow cytometric detection and quantitation of the epidermal growth factor receptor in comparison to Scatchard analysis in human bladder carcinoma cell lines. Cytometry. 1994 Sep 1;17(1):75-83. 
Übersichtsartikel Brockhoff G, Bock M, Mund A, Hauke S: mRNA HER2 FISH: A potential auxiliary cytogenetic tool for HER2 diagnosis in breast cancer. G.I.T. Imaging and Microscopy. 1/2010 12:32-35. ISSN 1439 Brockhoff G, Bock M, Mund A, Hauke S: mRNA HER2 FISH: A potential auxiliary cytogenetic tool for HER2 diagnosis in breast cancer. Europe BIOforum. Trends and Techniques in Life Science Research. G.I.T. 2010 Brockhoff G, Rothe G: DGfZ-ESCCA joint abstracts from The 18th Annual Meeting of The German Society of Cytometry (DGfZ) and The 8th Euroconference of Clinical Cell Analysis by The European Society for Clinical Cell Analysis (ESCCA). Cytometry B Clin Cytom. 2008 Oct 27;74B(6):377. Sassen A, Brockhoff G: M-FISH and QuantiFISH: Automated quantification of multicolor Fluorescence-in-situ-Hybridization in primary tissues. G.I.T. Imaging and Microscopy. 02/2008:46-49, 2008 Sassen A, Brockhoff G: M-FISH and QuantiFISH: Automated quantification of multicolor Fluorescence-in-situ-Hybridization in primary tissues. Europe BIOforum. Trends and Techniques in Life Science Research. G.I.T. 05/2008:42-44, 2008 Brockhoff G: 17th annual conference of the German Society of Cytometry – Welcome note. Cytometry Part A 71A: 739-741, 2007 Tarnok A, Brockhoff G: A Lifelong Dedication to Cytometry - A Tribute to Guenter Valet. 21 Aug, 2007 Published Online: Cytometry Part A. Brockhoff G: Cytomics and Receptor Interaction. Verh Dtsch Ges Path 2006 90:31-38 Tarnok A, Bocsi J, Brockhoff G. Cytomics - importance of multimodal analysis of cell function and proliferation in oncology. Cell Prolif. 2006 39(6):495-505 Tarnok A, Brockhoff G. Cytomics emerging from cytometry. Cell Prolif. 2006 Oct 39(5):335-8. Brockhoff G, Mueller S, Sarraf C, Tarnok A: Predictive Medicine and Clinical Cytomics Research - Résumé of the 15th Annual Meeting of the German Society for Cytometry (Deutsche Gesellschaft fuer Zytometrie, DGfZ), Cell Prolif, 2006 Apr;39(2):75-8 Brockhoff G, Knuechel R: Flow cytometric DNA-analysis in oncology: From single to multiparametric measurements. J Lab Med. 2003 Jun 27:5-6:167-174. Nap M, Brockhoff G, Brandt B, Knuechel R, Leers MP, Schmidt H, De Angelis G, Eltze E, Semjonow A. Flow cytometric DNA and phenotype analysis in pathology. A meeting report of a symposium at the annual conference of the German Society of Pathology, Kiel, Germany, 6-9 June 2000. Virchows Arch. 2001 May;438(5):425-32. Buchbeiträge Diermeier-Daucher S, Brockhoff G: Dynamic proliferations assessement in flow cytometry. Current Protocols in Cell Biology (CPCB), 2010 Brockhoff G: Flow Cytometric DNA und Proliferation Analysis. In: „Cellular Diagnostics – Principles, Methods and Clinical Applications in Flow Cytometry“. pp 390 – 425. ISBN-13: 978-3-8055-8555-2. Eds.: Sack, Rothe, Karger Publishing, 2009 Diermeier-Daucher S, Brockhoff G: Flow Cytometric FRET Analysis of (erbB-) Receptor-Tyrosine-Kinase Interaction. Curr Protoc Cytom (Ed.: J. Paul Robinson). 2008 Jul;Chapter 12:Unit12.14. ISBN: 1934-9297 Brockhoff G: DNA und Proliferationsmessungen in der Durchflusszytometrie. In: „Zelluläre Diagnostik – Grundlagen, Methoden und klinische Anwendungen der Durchflußzytometrie“. pp 604 – 646. Eds.: Sack, Rothe, Karger Verlag, Okt 2006 ISBN 3-8055-7928-4 Knuechel R, Brockhoff G, Endl E, Steinbach P: Durchflußzytometrie: Stand und Perspektiven in der onkologischen Diagnostik. In: Aktuelle Aspekte der Tumorimmunologie in der Gynäkologie, Kreienberg R, Grill HJ, Möbus V, Koldovsky U (Hrsg.), 1995 ISBN 3-88603-533-6 |
